Novel Interactions between Gut Microbiome and Host Drug-processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals PBDEs
نویسندگان
چکیده
244 words Introduction: 740 words Discussion: 2025 words Nonstandard Abbreviations: Abc, ATP-binding cassette; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; Cyp, cytochrome P450; CV, conventional; DPGs, drug-processing genes; GF, germ-free; Gst, glutathione S-transferase; LC-MS/MS, liquid chromatography tandem mass spectroscopy; Papss, 3'-phosphoadenosine 5'phosphosulfate synthase; PXR, pregnane X receptor; Slc, solute carrier; Sult, sulfotransferase; Ugt, UDP glucuronosyltransferase. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on September 1, 2017 as DOI: 10.1124/dmd.117.077024 at A PE T Jornals on Sptem er 6, 2017 dm d.aspurnals.org D ow nladed from
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